Design, synthesis, docking, molecular dynamics and bioevaluation studies on novel N-methylpicolinamide and thienopyrimidine derivatives with inhibiting NF-κB and TAK1 activities: Cheminformatics tools RDKit applied in drug design
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference42 articles.
1. Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors[J];Smale;Immunol. Rev.,2012
2. Inhibiting NF-κB activation by small molecules as a therapeutic strategy[J];Gupta;Biochim. Biophys. Acta,2010
3. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-κB signaling pathway in colon cancer cells[J];Yang;J. Cell. Physiol.,2010
4. Shared principles in NF-kappaB signaling[J];Hayden;Cell,2008
5. Nuclear factor-kappaB in cancer development and progression[J];Karin;Nature,2006
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