Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors

Author:

Van Dort Marcian E.,Jang Youngsoon,Bonham Christopher A.,Heist Kevin,Palagama Dilrukshika S.W.,McDonald LucasORCID,Zhang Edward Z.ORCID,Chenevert Thomas L.ORCID,Luker Gary D.ORCID,Ross Brian D.ORCID

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference38 articles.

1. MEK genomics in development and disease;Bromberg-White;Brief Funct Genomics,2012

2. MEK and PI3K inhibition in solid tumors: rationale and evidence to date;Jokinen;Ther Adv Med Oncol,2015

3. Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging;Steelman;Aging (N Y),2011

4. Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer;Saini;Cancer Treat Rev.,2013

5. Targeting alterations in the RAF-MEK pathway;Yaeger;Cancer Discov.,2019

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