Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs
Author:
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference22 articles.
1. The development of HEPT-type HIV non-nucleoside reverse transcriptase inhibitors and its implications for DABO family;Chen;Curr. Pharmaceut. Des.,2012
2. Contemporary medicinal chemistry strategies for the discovery and development of novel HIV-1 non-nucleoside reverse transcriptase inhibitors;Wang;J. Med. Chem.,2022
3. Expansion of the S-CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase;Ling;Eur. J. Med. Chem.,2022
4. Twenty years of therapy for HIV-1 infection;Pomerantz;Nat. Med.,2003
5. Druggability modification strategies of the diarylpyrimidine-type non-nucleoside reverse transcriptase inhibitors;Ding;Med. Res. Rev.,2021
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