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The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy

  • Published:2019-08 Issue: Volume:176 Page:92-104
  • ISSN:0223-5234
  • Container-title:European Journal of Medicinal Chemistry
  • language:en
  • Short-container-title:European Journal of Medicinal Chemistry

Author:

Liu Yao,Wang Xiaohui,Wang Guan,Yang Yushang,Yuan Yong,Ouyang LiangORCID

Funder

National Key R&D Program

National Natural Science Foundation of China

Sichuan Science and Technology Program

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference88 articles.

1. MDM2 and MDMX: alone and together in regulation of p53;Shadfan;Transl. Cancer Res.,2012

2. p53 and human cancer: the first ten thousand mutations;Hainaut;Adv. Cancer Res.,1999

3. P53 is a tumor suppressor gene;Levine;Cell,2004

4. AKT-dependent phosphorylation of Niban regulates nucleophosmin and MDM2-mediated p53 stability and cell apoptosis;Ji;EMBO Rep.,2012

5. c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation;Waning;J. Biol. Chem.,2011
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