Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain-Reference-Cited by-同舟云学术

Synthesis of a novel and potent small-molecule antagonist of PAC1 receptor for the treatment of neuropathic pain

Published:2020-01 Issue: Volume:186 Page:111902
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Takasaki Ichiro^ORCID,Ogashi Haruna,Okada Takuya,Shimodaira Ayaka,Hayakawa Daichi,Watanabe Ai,Miyata Atsuro,Kurihara Takashi,Gouda Hiroaki,Toyooka Naoki^ORCID

Funder

JSPS KAKENHI

Nakatomi Foundation

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference22 articles.

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2. Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38);Miyata;Biochem. Biophys. Res. Commun.,1990

3. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery;Vaudry;Pharmacol. Rev.,2009

4. VPAC and PAC receptors: from ligands to function;Dickson;Pharmacol. Ther.,2009

5. Maxadilan is a specific agonist and its deleted peptide (M65) is a specific antagonist for PACAP type 1 receptor;Uchida;Ann. N. Y. Acad. Sci.,1998

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