Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as IDO1/TDO dual inhibitors
Author:
Funder
CAMS
Key New Drug Creation and Manufacturing Program
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference51 articles.
1. Tryptophan-degrading enzymes in tumoral immune resistance;van Baren;Front. Immunol.,2015
2. Role of Ido and TDO in cancers and related diseases and the therapeutic implications;Ye;J. Cancer,2019
3. Targeting the inhibition of tryptophan 2,3-dioxygenase (TDO-2) for cancer treatment;Abdel-Magid;ACS Med. Chem. Lett.,2017
4. Modulation of tryptophan catabolism by regulatory T cells;Fallarino;Nat. Immunol.,2003
5. Indoleamine-2,3-dioxygenase, an immunosuppressive enzyme that inhibits natural killer cell function, as a useful target for ovarian cancer therapy;Wang;Int. J. Oncol.,2012
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