Discovery of 4’-trifluoromethylchalcones as novel, potent and selective hCYP1B1 inhibitors without concomitant AhR activation

Author:

Wu Yue,Shi Jin-Hui,Zhu Guang-Hao,Xiong Yuan,Gong Jia-Hao,Wei Hui-Zhen,Guo Zhao-Bin,Dai Zi-Ru,Sun Xiao-Bo,Ge Guang-Bo

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference64 articles.

1. The role of cytochrome P450 enzymes in endogenous signalling pathways and;Nebert;Environ. Carcinogenesis,2006

2. The activation of procarcinogens by CYP1A1/1B1 and related chemo-preventive agents;Li;a review,2021

3. Drug metabolizing enzymes-associated chemo resistance and strategies to overcome it;Verma;Drug Metab. Rev.,2019

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