Discovery of proteolysis-targeting chimera targeting undruggable proteins using a covalent ligand screening approach

Author:

Lee Hyeonjun,Lee Ju Yeon,Jang Hyunsoo,Cho Hye Young,Kang Minhee,Bae Sang Hyun,Kim Suin,Kim Eunji,Jang Jaebong,Kim Jin Young,Jeon Young HoORCID

Funder

Korea Basic Science Institute

National Research Foundation of Korea

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference37 articles.

1. Targeted protein degradation: a promise for undruggable proteins;Samarasinghe;Cell Chem. Biol.,2021

2. PROTAC targeted protein degraders: the past is prologue;Békés;Nat. Rev. Drug Discov.,2022

3. Protein-protein interactions: a structural view of inhibition strategies and the IL-23/IL-17 axis;Allen;Adv. Protein Chem.Struct.Biol.,2020

4. Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs;Alabi;J. Biol. Chem.,2021

5. Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4;Lu;Chem. Biol.,2015

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