Discovery of novel G9a/GLP covalent inhibitors for the treatment of triple-negative breast cancer
Author:
Funder
Sichuan Province Science and Technology Support Program
Sichuan University
West China Hospital, Sichuan University
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Pharmacology,General Medicine
Reference33 articles.
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3. G9a and glp methylate lysine 373 in the tumor suppressor p53;Huang;J. Biol. Chem.,2010
4. Methylation of DNA ligase 1 by G9a/GLP recruits UHRF1 to replicating DNA and regulates DNA methylation;Ferry;Mol. Cell.,2017
5. MYC interacts with the G9a histone methyltransferase to drive transcriptional repression and tumorigenesis;Tu;Cancer Cell,2018
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