Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins

Author:

Jiménez CarmenORCID,Ellahioui Younes,Álvarez Raquel,Aramburu Laura,Riesco Alejandra,González Myriam,Vicente Alba,Dahdouh Abdelaziz,Ibn Mansour Ahmed,Jiménez CarlosORCID,Martín Diego,Sarmiento Rogelio G.,Medarde Manuel,Caballero Esther,Peláez Rafael

Funder

Consejería de Educación de la Junta de Castilla y León

Spanish AECID

EU

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference67 articles.

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3. Antineoplastic agents. 84. Isolation and structure of combretastatin;Pettit;Can. J. Chem.,1982

4. Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study;Lin;Mol. Pharmacol.,1988

5. Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents;Penthala;Eur. J. Med. Chem.,2015

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