A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways

Author:

de Almeida Patricia D.O.,dos Santos Barbosa Jobim Gleyce,dos Santos Ferreira Caio César,Rocha Bernardes Lucas,Dias Rosane B.ORCID,Schlaepfer Sales Caroline B.,Valverde Ludmila de F.,Rocha Clarissa A.G.,Soares Milena B.P.,Bezerra Daniel P.,de Carvalho da Silva Fernando,Cardoso Mariana Filomena do Carmo,Ferreira Vitor Francisco,Brito Larissa F.,Pires de Sousa Lirlândia,de Vasconcellos Marne C.,Lima Emerson S.ORCID

Funder

FAPEAM

CNPq

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference62 articles.

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2. Biological evaluation of 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone as an anti-breast cancer agent;Kanaan;Anticancer Res.,2009

3. Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress;Wang;Proc. Natl. Acad. Sci. U.S.A.,2006

4. Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds;Hillard;Chem. Commun.,2008

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