Site-directed mutants, at position 166, of RTEM-1 beta-lactamase that form a stable acyl-enzyme intermediate with penicillin.
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference44 articles.
1. The structure of β-lactamases
2. ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.
3. The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 dd-peptidase family
4. Kinetics of inactivation of β-lactamase I by 6 β-bromopenicillanic acid
5. .beta.-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin
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