Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4-Reference-Cited by-同舟云学术

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Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4

Published:2019-01 Issue: Volume:412 Page:37-47
ISSN:0300-483X
Container-title:Toxicology
language:en
Short-container-title:Toxicology

Author:

Steinbrecht Susanne,König Rosalie,Schmidtke Kai-Uwe,Herzog Natalie,Scheibner Katrin,Krüger-Genge Anne,Jung Friedrich,Kammerer Sarah,Küpper Jan-Heiner

Funder

European Fonds of Regional Development

Ministry for Science, Research and Cultural Affairs of Brandenburg through the grant of the joint project

Publisher

Elsevier BV

Subject

Toxicology

Reference77 articles.

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2. Formation of the cytotoxic aldehyde acrolein during in vitro degradation of cyclophosphamide;Alarcon;Nature,1971

3. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells;Aninat;Drug Metab. Dispos.,2006

4. Measurement of 4-hydroxycyclophosphamide in serum by reversed-phase high-performance liquid chromatography;Belfayol;J. Chromatogr. B Biomed. Sci. Appl.,1995

5. DNA excision repair and DNA damage-induced apoptosis are linked to Poly(ADP-ribosyl)ation but have different requirements for p53;Beneke;Mol. Cell. Biol.,2000

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