Inhibition of TBK1 by amlexanox attenuates paraquat-induced acute lung injury

Author:

Wang Na,Li Yuhua,Wang Xiaofeng,Ma Zhongliang,Wang Yunwen,Zhang ChenORCID,Yuan Yuan,Zhao MinORCID

Funder

Natural Science Foundation of Liaoning Province

Publisher

Elsevier BV

Subject

Toxicology

Reference42 articles.

1. Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice;Amirshahrokhi;Int. Immunopharmacol.,2013

2. Nuclear factor-kappaB: a key regulator in health and disease of lungs;Batra;Arch. Immunol. Ther. Exp. (Warsz.),2011

3. Carboxylic acid derivatives of amlexanox display enhanced potency toward TBK1 and IKKepsilon and reveal mechanisms for selective inhibition;Beyett;Mol. Pharmacol.,2018

4. Paraquat and sustainable agriculture;Bromilow;Pest Manag. Sci.,2003

5. IKK epsilon deficiency attenuates angiotensin II-Induced abdominal aortic aneurysm formation in mice by inhibiting inflammation, oxidative stress, and apoptosis;Chai;Oxid. Med. Cell. Longev.,2020

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