8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity

Author:

Zhao Guolin,Xu Dengqiu,Yuan Ziqiao,Jiang Zhenzhou,Zhou Wang,Li Zhijian,Yin Mengyue,Zhou Zhixing,Zhang Luyong,Wang Tao

Funder

National Natural Science Foundation of China

Key development projects of Xinjiang Uygur Autonomous Region

Tianjin Research Program of Application Foundation and Advanced Technology

Public Interest Research of Traditional Chinese Medicine

National “Major Scientific and Technological Special Project for Significant New Drugs Creation” project

Publisher

Elsevier BV

Subject

Toxicology

Reference35 articles.

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2. Liver injury following administration of 8-methoxypsoralen during PUVA therapy;Bjellerup;Acta Derm. Venereol.,1979

3. Preparation and specific applications of isolated hepatocyte couplets;Boyer;Methods Enzymol.,1990

4. Cloning and regulation of the rat mdr2 gene;Brown;Nucleic Acids Res.,1993

5. Targeting the ABCB4 gene to control cholesterol homeostasis;Elferink;Expert Opin. Ther. Targets,2011

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