A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®

Author:

Bircsak Kristin M.,DeBiasio Richard,Miedel Mark,Alsebahi Alaa,Reddinger Ryan,Saleh Anthony,Shun TongyingORCID,Vernetti Lawrence A.,Gough Albert

Funder

NIH/NCATS Phase I and Phase II SBIR Contract

Publisher

Elsevier BV

Subject

Toxicology

Reference49 articles.

1. Mechanisms of immune-mediated liver injury;Adams;Toxicol. Sci.,2010

2. Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump;Aleo;Hepatology,2014

3. 3-D culture and endothelial cells improve maturity of human pluripotent stem cell-derived hepatocytes;Ardalani;Acta Biomater. Biomater. Cell Manuf. Tissue Biofab.,2019

4. Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism;Baillie;Drug Metab. Pharmacokinet.,2011

5. Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter study;Bell;Toxicol. Sci.,2018

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