Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine-Reference-Cited by-同舟云学术

Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine

Published:2023-12 Issue: Volume:500 Page:153692
ISSN:0300-483X
Container-title:Toxicology
language:en
Short-container-title:Toxicology

Author:

Akakpo Jephte Y.,Ramachandran Anup,Rumack Barry H.,Wallace Darren P.,Jaeschke Hartmut

Publisher

Elsevier BV

Subject

Toxicology

Reference77 articles.

1. Desorption electrospray ionization mass spectrometry imaging allows spatial localization of changes in acetaminophen metabolism in the liver after intervention with 4-methylpyrazole;Akakpo;J. Am. Soc. Mass Spectrom.,2022

2. Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole;Akakpo;Arch. Toxicol.,2021

3. Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose;Akakpo;Arch. Toxicol.,2022

4. Delayed treatment with 4-methylpyrazole protects against acetaminophen hepatotoxicity in mice by inhibition of c-jun n-terminal kinase;Akakpo;Toxicol. Sci.,2019

5. 4-methylpyrazole protects against acetaminophen-induced acute kidney injury;Akakpo;Toxicol. Appl. Pharmacol.,2020

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4. Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging;Toxicological Sciences;2024-01-30