The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA

Author:

Arai Tsuyoshi,Kelly Vincent P.,Minowa Osamu,Noda Tetsuo,Nishimura Susumu

Publisher

Elsevier BV

Subject

Toxicology

Reference24 articles.

1. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional/nwiAfhomoloque;Abrutani;Cancer Res.,1997

2. Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors;Al-Tassan;Nat. Genet.,2002

3. Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA;Arai;Cancer Res.,2003

4. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress;Arai;Carcinogenesis,2002

5. Inherited defects in the DNA glycosylase MYH cause multiple colorectal adenoma and carcinoma;Cheadle;Carcinogenesis,2003

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