Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome

Author:

Lang Gene A.,Iwakuma Tomoo,Suh Young-Ah,Liu Geng,Rao V.Ashutosh,Parant John M.,Valentin-Vega Yasmine A.,Terzian Tamara,Caldwell Lisa C.,Strong Louise C.,El-Naggar Adel K.,Lozano Guillermina

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference65 articles.

1. Post-translational modifications and activation of p53 by genotoxic stresses;Appella;Eur. J. Biochem,2001

2. P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1;Asher;Proc. Natl. Acad. Sci. USA,2003

3. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies;Bartek;Oncogene,1991

4. Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancer;Bataille;Mol. Pathol,2003

5. TP53 family members and human cancers;Benard;Hum. Mutat,2003

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