Anti-CD3 antibody ameliorates experimental autoimmune uveitis by inducing both IL-10 and TGF-β dependent regulatory T cells

Author:

Ke Yan,Jiang Guomin,Sun Deming,Kaplan Henry J.,Shao Hui

Funder

NIH

Vision Research Infrastructure Development

RPB Career Development Award

Lew R Wasserman Merit Award

Commonwealth of Kentucky Research Challenge Trust Fund

Publisher

Elsevier BV

Subject

Immunology,Immunology and Allergy

Reference37 articles.

1. Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis;Agarwal;J. Clin. Invest.,2000

2. Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance;Bagenstose;J. Immunol.,2005

3. TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes;Belghith;Nat. Med.,2003

4. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs;Bisikirska;J. Clin. Invest.,2005

5. Devising murine models to better adapt clinical protocols: sequential low-dose treatment with anti-CD3 and anti-CD4 monoclonal antibodies to prevent fully mismatched allograft rejection;Campos;Transplant. Proc.,1993

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