Inter-species variation in the metabolism and inhibition of N-[(2′-dimethylamino)ethyl]acridine-4-carboxamide (DACA) by aldehyde oxidase

Author:

Schofield Philip C,Robertson Iain G.C,Paxton James W

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference18 articles.

1. Selectivity of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide towards Lewis lung carcinoma and human tumour cell lines in vitro;Finlay;Eur J Cancer Clin Oncol,1989

2. Metabolism of the experimental antitumor agent acridine carboxamide in the mouse;Robertson;Drug Metab Dispos,1993

3. Cytosol mediated metabolism of the experimental antitumour agent acridine carboxamide to the 9-acridone derivative;Robertson;Biochem Pharmacol,1991

4. Rat hepatocyte-mediated metabolism of the experimental anti-tumour agent N-[2′-(dimethylamino)ethyl]acridine-4-carboxamide;Schlemper;Xenobiotica,1993

5. Studies on the metabolism of the novel antitumor agent [N-methyl-11C]N-[2-(dimethylamino)ethyl]-acridine-4-carboxamide in rats and humans prior to phase I clinical trials;Osman;Cancer Res,1997

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