Biocatalytic cascade process of islatravir: Analytical and regulatory control strategy of minor enantiomer

Author:

Chen YunORCID,Jo JunyongORCID,Hernandez Edgar,Wang Heather,Bernardoni Frank

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference26 articles.

1. 2′-Deoxy-4′-C-Ethynyl-2-Fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of hiv-1 strains, favorable toxic profiles, and stability in plasma;Ohrui;Nucl Nucl Nucl,2007

2. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms;Michailidis;J. Biol. Chem.,2014

3. Extended-duration MK-8591-eluting implant as a candidate for HIV treatment and prevention;Barrett;Antimicrob. Agents Chemother.,2018

4. World Heath Organization: HIV data and statistics. https://www.who.int/teams/ global-hiv-hepatitis-and-stis-programmes/hiv/strategic-information/hiv-data-and-statistics. (Accessed Apr 19 2023).

5. Enantioselective total synthesis of the potent Anti-HIV nucleoside EFdA;Kageyama;Org. Lett.,2011

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