Pharmacokinetic profile and metabolite identification of yuanhuapine, a bioactive component in Daphne genkwa by ultra-high performance liquid chromatography coupled with tandem mass spectrometry

Author:

Chen Yanyan,Guo Jianming,Tang Yuping,Wu Liang,Tao Weiwei,Qian Yefei,Duan Jin-ao

Funder

National Basic Research

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Spectroscopy,Drug Discovery,Pharmaceutical Science,Analytical Chemistry

Reference18 articles.

1. The Encyclopedia of Traditional Chinese Medicine;College,1985

2. Toxicity experiment on Sargassum, radix Knoxiae, radix Ransul and flos Genkwa against radix Glycyrrhizae in the antagonism of 18 Chinese drugs;Yang;Zhongguo Zhong Yao Za Zhi,1989

3. Evaluation of the indicative roles of seven potential biomarkers on hepato-nephrotoxicity induced by Genkwa Flos;Jiang;J. Ethnopharmacol.,2014

4. Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa;Zhan;Bioorgan. Med. Chem.,2005

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