Dose-response formation of N7-(3-benzo[1,3]dioxol-5-yl-2-hydroxypropyl)guanine in liver and urine correlates with micronucleated reticulocyte frequencies in mice administered safrole oxide

Author:

Wu Kuen-Yuh,Wei Yu-Tzu,Luo Yu-SyuanORCID,Shen Li-ChinORCID,Chang Bao-Suei,Chen Ya-Yin,Huang Yan-Chi,Huang Hui-Fen,Chung Wen-ShengORCID,Chiang Su-YinORCID

Funder

Ministry of Science and Technology

National Science Council

Ministry of Science and Technology, Taiwan

China Medical University

Publisher

Elsevier BV

Subject

Toxicology,General Medicine,Food Science

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3. Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1′-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1′-hydroxysafrole in mouse liver;Boberg;Cancer Res.,1983

4. The formation and biological significance of N7-guanine adducts;Boysen;Mutat. Res.,2009

5. Biological monitoring of environment exposure to safrole and the Taiwanese betel quid chewing;Chang;Arch. Environ. Contam. Toxicol.,2002

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