A convergent, scalable and stereoselective synthesis of azole CYP51 inhibitors-Reference-Cited by-同舟云学术

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A convergent, scalable and stereoselective synthesis of azole CYP51 inhibitors

Published:2017-11 Issue:45 Volume:58 Page:4248-4250
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Lepesheva Galina,Christov Plamen,Sulikowski Gary A.,Kim Kwangho

Funder

National Institutes of General Health

Vanderbilt Institute of Chemical Biology

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference21 articles.

1. Sterol 14α-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

2. Sterol 14alpha-Demethylase (CYP51) as a Therapeutic Target for Human Trypanosomiasis and Leishmaniasis

3. Sterol 14α-Demethylase as a Potential Target for Antitrypanosomal Therapy: Enzyme Inhibition and Parasite Cell Growth

4. Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

5. The Role of Fluorine Substitution in Biphenyl Methylene Imidazole-Type CYP17 Inhibitors for the Treatment of Prostate Carcinoma

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1. Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target;Journal of Medicinal Chemistry;2024-04-29

2. Relaxed Substrate Requirements of Sterol 14α-Demethylase from Naegleria fowleri Are Accompanied by Resistance to Inhibition;Journal of Medicinal Chemistry;2021-11-29

3. Organic Antifungal Drugs and Targets of Their Action;Current Topics in Medicinal Chemistry;2021-05-03

4. Ten-Year Retrospective of the Vanderbilt Institute of Chemical Biology Chemical Synthesis Core;ACS Chemical Biology;2021-04-20

5. The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication;Antimicrobial Agents and Chemotherapy;2020-09-21

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