A facile one-pot synthesis of acyclic β-enamino ketones, an important class of versatile synthetic intermediates

Author:

Choudhury Anusuya,Breslav Michael,Grimm Jeffrey S.,Xiao Tong,Xu Dawei,Sorgi Kirk L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference16 articles.

1. N-methoxy-n-methylamides as effective acylating agents

2. CHEMISTRY OF N-METHOXY-N-METHYLAMIDES. APPLICATIONS IN SYNTHESIS. A REVIEW

3. Choudhury, A; Grimm, J. S.; Jones, T. K.; Liang, J. T.; Mani, N; Sorgi, K. L. WO 2005/005393.

4. The content of this manuscript and related work were presented at the following symposiums: (1) A facile one-pot synthesis of β-enamino ketones: A masked diketone with distinct reactivity difference. Choudhury, A; Grimm, J. S.; Sorgi, K. L; Xiao, T; Breslav, M; Xu, D.; Presented at the 230th ACS National Meeting, Washington, DC, United States, August 28–September 1, 2005. (2) Novel and highly regioselective synthesis of substituted pyrazoles. Grimm, J. S.; Callahan, R.; Choudhury, A.; Segmuller, B.; Sorgi, K. L.; Xiao, T; Xu, D. Presented at the 229th ACS National Meeting, San Diego, CA, United States, March 13–17, 2005.

5. Very recently, we came across a communication, which describes synthesis of a substrate similar to 4a via analogous method as disclosed in our patent application, WO 2005/005393 (Persson, T., Nielsen, J. Org. Lett. 2006, 8, 3219).

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