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A novel role of IL-17A in contributing to the impaired suppressive function of Tregs in psoriasis

  • Published:2021-02 Issue:2 Volume:101 Page:84-92
  • ISSN:0923-1811
  • Container-title:Journal of Dermatological Science
  • language:en
  • Short-container-title:Journal of Dermatological Science

Author:

Liu Yanghe,Zhang Chen,Li Bing,Yu Chen,Bai Xiaocui,Xiao Chunying,Wang Lei,Dang Erle,Yang Luting,Wang Gang

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Dermatology,Molecular Biology,Biochemistry

Reference19 articles.

1. Scanning the immunopathogenesis of psoriasis;Chiricozzi;Int. J. Mol. Sci.,2018

2. IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells;Goodman;J. Immunol. (Baltimore, Md. : 1950),2009

3. Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3;Yang;J. Dermatol. Sci.,2016

4. Dysregulation of Akt-FOXO1 pathway leads to dysfunction of regulatory t cells in patients with psoriasis;Li;J. Invest. Dermatol.,2019

5. Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing αβ T cell clones;Matos;J. Clin. Invest.,2017
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