Inhibition of SGLT2 co-transporter by dapagliflozin ameliorates tubular proteinuria and tubule-interstitial injury at the early stage of diabetic kidney disease

Author:

Farias Raysa S.,Silva-Aguiar Rodrigo P.,Teixeira Douglas E.,Gomes Carlos P.,Pinheiro Ana Acacia S.,Peruchetti Diogo B.,Caruso-Neves CelsoORCID

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Publisher

Elsevier BV

Subject

Pharmacology

Reference77 articles.

1. Diabetic kidney disease: challenges, progress, and possibilities;Alicic;Clin. J. Am. Soc. Nephrol.,2017

2. Empagliflozin alleviates renal inflammation and oxidative stress in streptozotocin-induced diabetic rats partly by repressing HMGB1-TLR4 receptor axis;Ashrafi Jigheh;Iran J. Basic Med. Sci.,2019

3. Sodium-glucose cotransporter 2 inhibition suppresses HIF-1α-mediated metabolic switch from lipid oxidation to glycolysis in kidney tubule cells of diabetic mice;Cai;Cell Death Dis.,2020

4. PKB and megalin determine the survival or death of renal proximal tubule cells;Caruso-Neves;Proc. Natl. Acad. Sci. U. S. A.,2006

5. SGLT2 inhibitor dapagliflozin limits podocyte damage in proteinuric nondiabetic nephropathy;Cassis;JCI Insight,2018

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