Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition-Reference-Cited by-同舟云学术

Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition

Published:2021-12 Issue:24 Volume:433 Page:167309
ISSN:0022-2836
Container-title:Journal of Molecular Biology
language:en
Short-container-title:Journal of Molecular Biology

Author:

Dekker Carien,Mattes Henri,Wright Michael,Boettcher Andreas,Hinniger Alexandra,Hughes Nicola,Kapps-Fouthier Sandra,Eder Jörg,Erbel Paulus,Stiefl Nikolaus,Mackay Angela,Farady Christopher J.

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference35 articles.

1. Targeting the NLRP3 inflammasome in inflammatory diseases;Mangan;Nature Rev. Drug Discov.,2018

2. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals;Duewell;Nature,2010

3. Gout-associated uric acid crystals activate the NALP3 inflammasome;Martinon;Nature,2006

4. Cryopyrin activates the inflammasome in response to toxins and ATP;Mariathasan;Nature,2006

5. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice;Heneka;Nature,2013

Cited by 90 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1;Biochemical Pharmacology;2024-09

2. Targeting COVID-19 and varicocele by blocking inflammasome: Ligand-based virtual screening;Archives of Biochemistry and Biophysics;2024-09

3. Novel NLRP3 inhibitor INF195: Low doses provide effective protection against myocardial ischemia/reperfusion injury;Vascular Pharmacology;2024-09

4. Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis;Journal of Medicinal Chemistry;2024-08-22

5. NLRP3 Negative Regulation Mechanisms in the Resting State and Its Implications for Therapeutic Development;International Journal of Molecular Sciences;2024-08-20