Cathelicidin LL-37 Activates Human Keratinocyte Autophagy through the P2X₇, Mechanistic Target of Rapamycin, and MAPK Pathways

Author:

Ikutama RisaORCID,Peng GeORCID,Tsukamoto SayaORCID,Umehara YoshieORCID,Trujillo-Paez Juan ValentinORCID,Yue HainanORCID,Nguyen Hai Le ThanhORCID,Takahashi MihoORCID,Kageyama ShunORCID,Komatsu MasaakiORCID,Okumura KoORCID,Ogawa HideokiORCID,Ikeda ShigakuORCID,Niyonsaba FrançoisORCID

Funder

National Eczema Association

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Elsevier BV

Subject

Cell Biology,Dermatology,Molecular Biology,Biochemistry

Reference58 articles.

1. Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers;Aberg;J Invest Dermatol,2008

2. Constitutive autophagy and nucleophagy during epidermal differentiation;Akinduro;J Invest Dermatol,2016

3. The human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function;Akiyama;J Innate Immun,2014

4. P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death;Bian;PLoS One,2013

5. Tissue-specific regulation of innate immune responses by human cathelicidin LL-37;Chieosilapatham;Curr Pharm Des,2018

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