l-carnosine dipeptide overcomes acquired resistance to 5-fluorouracil in HT29 human colon cancer cells via downregulation of HIF1-alpha and induction of apoptosis

Author:

Iovine Barbara,Guardia Francesca,Irace Carlo,Bevilacqua Maria Assunta

Publisher

Elsevier BV

Subject

General Medicine,Biochemistry

Reference34 articles.

1. Targeting HIF-1 for cancer therapy;Semenza;Nat. Rev. Cancer,2003

2. The anti-proliferative effect of L-carnosine correlates with a decreased expression of hypoxia inducible factor 1 alpha in human colon cancer cells;Iovine;PLoS One,2014

3. Mechanisms of multidrug resistance in cancer;Gillet;Methods Mol. Biol.,2010

4. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene;Comerford;Cancer Res.,2002

5. HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression;Koshiji;Mol. Cell,2005

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