Advances and hurdles to clinical translation of RNAi therapeutics

Author:

Kwon Ick Chan,Kataoka Kazunori

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference5 articles.

1. Induction of a highly specific antiviral state in transgenic plants: Implications for regulation of gene expression and virus resistance;Lindbo;The Plant Cell,1993

2. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans;Fire;Nature,1998

3. E. Bender, The second coming of RNAi, TheScientis (2014) September 1.

4. Is RNAi dead?;Krieg;Molecular Therapy,2011

5. M. Mason, Alnylam receives orphan drug designation from the United States Food & Drug Administration for revusiran, an investigational RNAi therapeutic for the treatment of transthyretin (TTR)-mediated amyloidosis (ATTR Amyloidosis), Business Wire (2015) May 20.

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