The MAGIC trial: a pragmatic, multicentre, parallel, noninferiority, randomised trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia

Author:

Bolt RobertORCID,Hyslop Marie C.ORCID,Herbert EstherORCID,Papaioannou Diana E.ORCID,Totton NikkiORCID,Wilson Matthew J.ORCID,Clarkson JanetORCID,Evans ChristopherORCID,Ireland NicholasORCID,Kettle JenniferORCID,Marshman Zoe,Norrington Amy C.ORCID,Paton Robert H.,Vernazza ChristopherORCID,Deery ChristopherORCID,Albadri Sondos,Armstrong Laura,Atkins Simon,Babb Margaret,Biercamp Claire,Biggs Katie,Bradburn Mike,Buckley Jaimie,Child-Cavill Julie,Cope Sean,Crawley Simon,Dimairo Munya,Duro Enass,Eissa Ayman,Flight Laura,Gath Jacqui,Gavel Gil,Geary Tim,Gilchrist Fiona,Gopal Padma,Hall Jamie,Hutchence Kate,Khandelwal Puran,Kukreja Pranav,Leeuwenberg Ian,Limb James,Loban Amanda,Mellor Katie,Masip Nuria,Moores Anthony,Oshan Vimmi,Pickles Edward,Ray Jaydip,Rodd Helen,Rolfe Sian,Sheldon Elena,Simmonds Richard,Smith Rachel,Sundar Ashok,Thomason Anna,Waterhouse Simon,Wilson Graham,Yates Julian,Young Tracey

Funder

Health Technology Assessment Programme

Publisher

Elsevier BV

Subject

Anesthesiology and Pain Medicine

Reference39 articles.

1. The state of UK pediatric anesthesia: a survey of National Health Service activity;Sury;Paediatr Anaesth,2015

2. Deery C, Bolt R, Papaioannou D, et al. The MAGIC trial (Melatonin for Anxiety prior to General anaesthesia In Children): a multicentre, parallel randomised controlled trial of melatonin versus midazolam in the premedication of anxious children attending for elective surgery under general anaesthesia. 2023. The University of Sheffield. Workflow. Available from: https://doi.org/10.15131/shef.data.22220884.v1 (accessed 23 March 2023)

3. Healthcare provider and parent behavior and children's coping and distress at anesthesia induction;Chorney;Anesthesiology,2009

4. Medical clowns reduce pre-operative anxiety, post-operative pain and medical costs in children undergoing outpatient penile surgery: a randomised controlled trial;Kocherov;J Paediatr Child Health,2016

5. Induction and emergence behavior of children undergoing general anesthesia correlates with maternal salivary amylase activity before the anesthesia;Arai;Acta Anaesthesiol Scand,2008

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