Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement-Reference-Cited by-同舟云学术

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Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

Published:2018-02 Issue:2 Volume:25 Page:206-214.e11
ISSN:2451-9456
Container-title:Cell Chemical Biology
language:en
Short-container-title:Cell Chemical Biology

Author:

Vasta James D.,Corona Cesear R.,Wilkinson Jennifer,Zimprich Chad A.,Hartnett James R.,Ingold Morgan R.,Zimmerman Kristopher,Machleidt Thomas,Kirkland Thomas A.,Huwiler Kristin G.,Ohana Rachel Friedman,Slater Michael,Otto Paul,Cong Mei,Wells Carrow I.,Berger Benedict-Tilman,Hanke Thomas,Glas Carina,Ding Ke,Drewry David H.,Huber Kilian V.M.,Willson Timothy M.,Knapp Stefan,Müller Susanne,Meisenheimer Poncho L.,Fan Frank,Wood Keith V.,Robers Matthew B.

Funder

AbbVie

Bayer Pharma

Boehringer Ingelheim

Canada Foundation for Innovation

Eshelman Institute for Innovation

Genome Canada

Ontario Genomics Institute

Innovative Medicines Initiative (EU/EFPIA)

Janssen

Merck

MSD

Novartis Pharma

Ontario Ministry of Research, Innovation and Science

Pfizer

São Paulo Research Foundation - FAPESP

Takeda

Wellcome Trust

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,Biochemistry

Reference46 articles.

1. The promise and peril of chemical probes;Arrowsmith;Nat. Chem. Biol.,2015

2. Affinity profiling of the cellular kinome for the nucleotide cofactors ATP, ADP, and GTP;Becher;ACS Chem. Biol.,2013

3. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction;Cheng;Biochem. Pharmacol.,1973

4. A type-II kinase inhibitor capable of inhibiting the T315I “gatekeeper” mutant of Bcr-Abl;Choi;J. Med. Chem.,2010

5. Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK);Cui;J. Med. Chem.,2011

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