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3. For examples of ‘tropane-like’ scaffolds, see: (a) Thompson, P. E.; Steer, D. L.; Aguilar, M. I.; Hearn, M. T. W. Bioorg. Med. Chem. Lett. 1998, 8, 2699–2704. (b) Koh, J. S.; Ellman, J. A. J. Org. Chem. 1996, 61, 4494–4495.
4. (a) Lounasmaa, M.; Tamminen, T. The Alkaloïds 1993, 44, 1–115.
5. (b) Doda, M.; Gyorgy, L.; Nàdor, K. Arch. Int. Pharmacodyn. 1963, 145, 264–275.