Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance

Author:

Gjuka Donjeta,Adib Elio,Garrison Kendra,Chen Jianfeng,Zhang Yuxue,Li Wenjiao,Boutz Daniel,Lamb Candice,Tanno Yuri,Nassar Amin,El Zarif Talal,Kale Neil,Rakaee Mehrdad,Mouhieddine Tarek H.,Alaiwi Sarah Abou,Gusev Alexander,Rogers Thomas,Gao Jianjun,Georgiou George,Kwiatkowski David J.,Stone EverettORCID

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference80 articles.

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3. Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-α1, interferon-β1, and other 9p21 markers in human malignant cell lines;Zhang;Cancer Genet. Cytogenet.,1996

4. Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas;Illei;Clin. Cancer Res.,2003

5. Downregulation of methylthioadenosin phosphorylase by homozygous deletion in gastric carcinoma;Kim;Genes Chromosomes Cancer,2011

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