Vaccine-associated respiratory pathology correlates with viral clearance and protective immunity after immunization with self-amplifying RNA expressing the spike (S) protein of SARS-CoV-2 in mouse models

Author:

Kachko AllaORCID,Selvaraj PrabhuanandORCID,Liu ShufengORCID,Kim JaekwanORCID,Rotstein David,Stauft Charles B.ORCID,Chabot SylvieORCID,Rajasagi Naveen,Zhao YangqingORCID,Wang TonyORCID,Major Marian

Funder

U.S. Food and Drug Administration

Publisher

Elsevier BV

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,General Veterinary,General Immunology and Microbiology,Molecular Medicine

Reference56 articles.

1. EMA. Authorised COVID-19 vaccines. European Medicines Agency; 2020. Last accessed November 2023. https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19/covid-19-medicines#authorised-covid-19-vaccines-section.

2. FDA US. COVID-19 Vaccines. U.S. Food and Drug Administration; 2020. Last accessed November, 2023. https://www.fda.gov/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/covid-19-vaccines.

3. Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus;Fleeton;J Infect Dis,2001

4. Utility of the Sindbis replicon system as an Env-targeted HIV vaccine;Center;Vaccine,2013

5. Alphavirus-based expression vectors: strategies and applications;Frolov;Proc Natl Acad Sci U S A,1996

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