Optimized CAR-T therapy based on spatiotemporal changes and chemotactic mechanisms of MDSCs induced by hypofractionated radiotherapy

Author:

Zhang Benxia,Hu Min,Ma Qizhi,Li Kai,Li Xue,He Xia,Shu Pei,Chen Yue,Gao Ge,Qin Diyuan,Guo Fuchun,Zhao Jian,Liu Ning,Zhou Kexun,Feng MingYang,Liao Weiting,Li Dan,Wang Xin,Wang YongshengORCID

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference50 articles.

1. Chimeric antigen receptor T cells for sustained remissions in leukemia;Maude;N. Engl. J. Med.,2014

2. Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors;Zhang;Mol. Cancer,2018

3. Key chemokines direct migration of immune cells in solid tumors;Kohli;Cancer Gene Ther.,2022

4. T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours;Lesch;Nat. Biomed. Eng.,2021

5. Selectively targeting myeloid-derived suppressor cells through TRAIL receptor 2 to enhance the efficacy of CAR T cell therapy for treatment of breast cancer;Nalawade;J. Immunother. Cancer,2021

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Time to abandon CAR-T monotherapy for solid tumors;Biochimica et Biophysica Acta (BBA) - Reviews on Cancer;2023-07

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