Inadvertent Germline Transmission of AAV2 Vector: Findings in a Rabbit Model Correlate with Those in a Human Clinical Trial

Author:

Schuettrumpf Joerg,Liu Jian-Hua,Couto Linda B.,Addya Kathakaly,Leonard Debra G.B.,Zhen Zhu,Summer Jürg,Arruda Valder R.

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference33 articles.

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3. Germline alteration by gene therapy: assessing and reducing the risk;Gordon;Mol. Med. Today,1998

4. Use of adeno-associated virus as a general transduction vector in mammalian cells;Muzcyzka;Curr. Topics Microbiol. Immunol.,1992

5. AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B;Manno;Blood,2003

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