Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes

Author:

Banno Yoshihiro,Sasaki Shigekazu,Kamata Makoto,Kunitomo Jun,Miyamoto Yasufumi,Abe Hidenori,Taya Naohiro,Oi Satoru,Watanabe Masanori,Urushibara Tomoko,Hazama Masatoshi,Niwa Shin-ichi,Miyamoto Saku,Horinouchi Akira,Kuroshima Ken-ichi,Amano Nobuyuki,Matsumoto Shin-ichi,Matsunaga Shinichiro

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. The essential role of glucagon in the pathogenesis of diabetes mellitus;Unger;Lancet,1975

2. Glucagon: role in the hyperglycemia of diabetes mellitus;Dobbs;Science,1975

3. Hansen LH, Larger E, Chaput JC, et al. Identification of a hGluR Gene Deletion Mutation in a Patient with Hyperglucagonemia and Pseudoadenomatous Hyperplasia of Pancreatic Alpha-Cells. Presented at the 81st Annual Meeting of the Endocrine Society, San Diego, CA, June 12–15, 1999; P3–441.

4. Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5;Cordelier;Proc Natl Acad Sci,1997

5. Specific inhibition of rat pancreatic insulin and glucagon release by receptor-selective somatostatin analogues;Rossowski;Biochem Biophys Res Comm,1994

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