Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial

Author:

Datoo Mehreen S,Dicko Alassane,Tinto Halidou,Ouédraogo Jean-Bosco,Hamaluba Mainga,Olotu Ally,Beaumont Emma,Ramos Lopez Fernando,Natama Hamtandi Magloire,Weston Sophie,Chemba Mwajuma,Compaore Yves Daniel,Issiaka Djibrilla,Salou Diallo,Some Athanase M,Omenda Sharon,Lawrie Alison,Bejon Philip,Rao Harish,Chandramohan Daniel,Roberts Rachel,Bharati Sandesh,Stockdale Lisa,Gairola Sunil,Greenwood Brian M,Ewer Katie J,Bradley John,Kulkarni Prasad S,Shaligram Umesh,Hill Adrian V S,Mahamar Almahamoudou,Sanogo Koualy,Sidibe Youssoufa,Diarra Kalifa,Samassekou Mamoudou,Attaher Oumar,Tapily Amadou,Diallo Makonon,Dicko Oumar Mohamed,Kaya Mahamadou,Maguiraga Seydina Oumar,Sankare Yaya,Yalcouye Hama,Diarra Soumaila,Niambele Sidi Mohamed,Thera Ismaila,Sagara Issaka,Sylla Mala,Dolo Amagana,Misidai Nsajigwa,Simando Sylvester,Msami Hania,Juma Omary,Gutapaka Nicolaus,Paul Rose,Mswata Sarah,Sasamalo Ibrahim,Johaness Kasmir,Sultan Mwantumu,Alexander Annastazia,Kimaro Isaac,Lwanga Kauye,Mtungwe Mwajuma,Khamis Kassim,Rugarabam Lighton,Kalinga Wilmina,Mohammed Mohammed,Kamange Janeth,Msangi Jubilate,Mwaijande Batuli,Mtaka Ivanny,Mhapa Matilda,Mlaganile Tarsis,Mbaga Thabit,Yerbanga Rakiswende Serge,Samtouma Wendkouni,Sienou Abdoul Aziz,Kabre Zachari,Ouedraogo Wendinpui Jedida Muriel,Yarbanga G Armel Bienvenu,Zongo Issaka,Savadogo Hamade,Sanon Joseph,Compaore Judicael,Kere Idrissa,Yoni Ferdinand Lionel,Sanre Tewende Martine,Ouattara Seydou Bienvenu,Provstgaard-Morys Samuel,Woods Danielle,Snow Robert W.,Amek Nyaguara,Ngetsa Caroline J.,Ochola-Oyier Lynette Isabella,Musyoki Jennifer,Munene Marianne,Mumba Noni,Adetifa Uche Jane,Muiruri Charles Mwangi,Mwawaka Jimmy Shangala,Mwaganyuma Mwatasa Hussein,Ndichu Martha Njeri,Weya Joseph Ochieng,Njogu Kelvin,Grant Jane,Webster Jayne,Lakhkar Anand,Ido N. Félix André,Traore Ousmane,Tahita Marc Christian,Bonko Massa dit Achille,Rouamba Toussaint,Ouedraogo D. Florence,Soma Rachidatou,Millogo Aida,Ouedraogo Edouard,Sorgho Faizatou,Konate Fabé,Valea Innocent

Funder

Serum Institute of India Pvt Ltd

Publisher

Elsevier BV

Reference8 articles.

1. World malaria report 2022,2022

2. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial;Lancet,2015

3. Ultra-low dose immunization and multi-component vaccination strategies enhance protection against malaria in mice;Collins;Sci Rep,2021

4. Enhancing protective immunity to malaria with a highly immunogenic virus-like particle vaccine;Collins;Sci Rep,2017

5. Phase I assessments of first-in-human administration of a novel malaria anti-sporozoite vaccine candidate, R21 in matrix-M adjuvant, in UK and Burkinabe volunteers;Venkatraman;medRxiv,2019

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