GRP78-CAR T cell effector function against solid and brain tumors is controlled by GRP78 expression on T cells

Author:

Ibanez Jorge,Hebbar Nikhil,Thanekar Unmesha,Yi Zhongzhen,Houke Haley,Ward Meghan,Nevitt Chris,Tian Liqing,Mack Stephen C.,Sheppard Heather,Chiang Jason,Velasquez M. Paulina,Krenciute GiedreORCID

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference50 articles.

1. CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment;Martinez;Front. Immunol.,2019

2. Engineering strategies to overcome the current roadblocks in CAR T cell therapy;Rafiq;Nat. Rev. Clin. Oncol.,2020

3. HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial;Ahmed;JAMA Oncol.,2017

4. Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy;Brown;N. Engl. J. Med.,2016

5. A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma;O'Rourke;Sci. Transl. Med.,2017

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