Dolutegravir dosing for children with HIV weighing less than 20 kg: pharmacokinetic and safety substudies nested in the open-label, multicentre, randomised, non-inferiority ODYSSEY trial

Author:

Waalewijn Hylke,Chan Man K,Bollen Pauline D J,Mujuru Hilda A,Makumbi Shafic,Kekitiinwa Adeodata R,Kaudha Elizabeth,Sarfati Tatiana,Musoro Godfrey,Nanduudu Annet,Lugemwa Abbas,Amuge Pauline,Moore Cecilia L,Rojo Pablo,Giaquinto Carlo,Colbers Angela,Gibb Diana M,Ford Deborah,Turkova Anna,Burger David M

Publisher

Elsevier BV

Subject

Virology,Infectious Diseases,Immunology,Epidemiology

Reference21 articles.

1. Update of recommendations on first- and second-line antiretroviral regimens,2019

2. Clinical pharmacokinetics and pharmacodynamics of dolutegravir used as a single tablet regimen for the treatment of HIV-1 infection;Bollen;Expert Opin Drug Saf,2015

3. Simplified dolutegravir dosing for children with HIV weighing 20 kg or more: pharmacokinetic and safety substudies of the multicentre, randomised ODYSSEY trial;Bollen;Lancet HIV,2020

4. Waalewijn H, Mujuru HA, Amuge P, et al. Adequate dolutegravir exposure dosed BID with rifampicin in children 6 to <18 years. Conference on Retroviruses and Opportunistic Infections; March 11, 2020 (abstr 847).

5. Relative bioavailability of a dolutegravir dispersible tablet and the effects of low- and high-mineral-content water on the tablet in healthy adults;Buchanan;Clin Pharmacol Drug Dev,2017

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