SARS-CoV-2 spike protein receptor binding domain promotes IL-6 and IL-8 release via ATP/P2Y2 and ERK1/2 signaling pathways in human bronchial epithelia

Author:

Zhang Rui-Gang,Liu Xing-Jian,Guo Yu-Ling,Chen Chun-Ling

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Reference36 articles.

1. Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells;Asokananthan;J. Immunol.,2002

2. SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation;Bezzerri;Nat. Commun.,2023

3. SARS-CoV-2 spike proteins and cell-cell communication induce P-selectin and markers of endothelial injury, NETosis, and inflammation in human lung microvascular endothelial cells and neutrophils: implications for the pathogenesis of COVID-19 Coagulopathy;Bhargavan;Int. J. Mol. Sci.,2023

4. SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling;Biering;Nat. Commun.,2022

5. Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33;Calven;J. Transl. Med.,2015

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