Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma

Author:

Chen Ming,Lv Zhiqiang,Zhang Wei,Huang Linjie,Lin Xiaoling,Shi Jianting,Zhang Wei,Liang Ruiyun,Jiang Shanping

Funder

Sun Yat-sen University

National Natural Science Foundation of China

Guangdong Natural Science Foundation

Publisher

Elsevier BV

Subject

Molecular Biology,Immunology

Reference27 articles.

1. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression;Chakir;J. Allergy Clin. Immunol.,2003

2. Triptolide inhibits tumor promoter-induced uPAR expression via blocking NF-kappaB signaling in human gastric AGS cells;Chang;Anticancer Res.,2007

3. The NF-kappaB-independent functions of IKK subunits in immunity and cancer;Chariot;Trends Cell Biol.,2009

4. IL-1beta induction of MUC5AC gene expression is mediated by CREB and NF-kappaB and repressed by dexamethasone;Chen;Am. J. Physiol. Lung Cell Mol. Physiol.,2014

5. Regulated airway goblet cell mucin secretion;Davis;Annu. Rev. Physiol.,2008

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