Pharmacokinetics, excretion, distribution, and metabolism of 60-kDa polyethylene glycol used in BAY 94-9027 in rats and its value for human prediction

Author:

Baumann Andreas,Piel Isabel,Hucke Frank,Sandmann Steffen,Hetzel Terence,Schwarz Thomas

Funder

Bayer

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference42 articles.

1. Full Prescribing Information;Adynovate (antihemophilic factor [recombinant], PEGylated),2017

2. Current challenges in the management of hemophilia;Bauer;Am. J. Manag. Care,2015

3. Pharmacokinetics and excretion of 14C-labeled polyethylene glycol (60 kDa) in rats;Baumann;Blood,2014

4. Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?;Baumann;Drug Discov. Today,2014

5. 40 kDa PEG of N9-GP is eliminated from tissues and will reach steady state after chronic dosing;Bjoernsdottir,2017

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