Safrole induced cytotoxicity, DNA damage, and apoptosis in macrophages via reactive oxygen species generation and Akt phosphorylation

Author:

Chien Kuang-Jen,Yang Ming-Ling,Tsai Ping-Kun,Su Chun-Hung,Chen Chia-Hui,Horng Chi-Ting,Yeh Chung-Hsin,Chen Wen-Ying,Lin Meng-Liang,Chen Chun-Jung,Chian Chen-Yu,Kuan Yu-HsiangORCID

Funder

Ministry of Science and Technology of Taiwan

Publisher

Elsevier BV

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,General Medicine

Reference40 articles.

1. Partial role of multiple pathways in infarct size limiting effect of quercetin and rutin against cerebral ischemia–reperfusion injury in rats;Annapurna;Eur. Rev. Med. Pharmacol. Sci.,2013

2. Safrole-like DNA adducts in oral tissue from oral cancer patients with a betel quid chewing history;Chen;Carcinogenesis,1999

3. Enhanced hydroxychavicol-induced cytotoxic effects in glutathione-depleted HepG2 cells;Chen;Cancer Lett.,2000

4. Protective effect of rutin on LPS-induced acute lung injury via down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation;Chen;Int. Immunopharmacol.,2014

5. Polarization of tumor-associated macrophages and Gas6/Axl signaling in oral squamous cell carcinoma;Chiu;Oral Oncol.,2015

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