Enhanced brain targeting by synthesis of 3′,5′-dioctanoyl-5-fluoro-2′-deoxyuridine and incorporation into solid lipid nanoparticles

Author:

Wang Jian-Xin,Sun Xun,Zhang Zhi-Rong

Publisher

Elsevier BV

Subject

Pharmaceutical Science,General Medicine,Biotechnology

Reference17 articles.

1. Solid lipid nanoparticles: production, characterization and applications;Mehnert;Adv. Drug Deliv. Rev.,2001

2. Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the art;Muller;Eur. J. Pharm. Biopharm.,2000

3. 3′,5′-diesters of 5-fluoro-2′-deoxyuridine: synthesis and biological activity;Oshihiko;Biochem. Pharmacol.,1965

4. Selective antiancer effects of 3′,5′-dioctanoyl-5-fluoro-2′-deoxyuridine, a lipophilic prodrug of 5-fluoro-2′-deoxyuridine dissolved in an oily lymphographic agent on hepatic cancer of rabbits bearing VX-2 tumor;Shoji;Cancer Res.,1987

5. 3′,5′-diesters of 5-fluoro-2′-deoxyuridine: synthesis and biological activity;Nishizawa;Biochem. Pharmacol.,1965

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