Gender and incidence of dementia in the Framingham Heart Study from mid‐adult life

Author:

Chêne Geneviève1,Beiser Alexa23,Au Rhoda2,Preis Sarah R.3,Wolf Philip A.2,Dufouil Carole1,Seshadri Sudha2

Affiliation:

1. Inserm U897 and CIC‐EC7 University of Bordeaux Segalen, Isped (Bordeaux School of Public Health) CHU de Bordeaux Bordeaux France

2. Department of Neurology Boston University School of Medicine Boston MA USA

3. Department of Biostatistics Boston University School of Public Health Boston MA USA

Abstract

BackgroundGender‐specific risks for dementia and Alzheimer's disease (AD) starting in midlife remain largely unknown.MethodsProspectively ascertained dementia/AD and cause‐specific mortality in Framingham Heart Study (FHS) participants was used to generate 10‐ to 50‐year risk estimates of dementia/AD on the basis of the Kaplan–Meier method (cumulative incidence) or accounting for competing risk of death (lifetime risk [LTR]).ResultsOverall, 777 cases of incident dementia (601 AD) occurred in 7901 participants (4333 women) over 136,266 person‐years. Whereas cumulative incidences were similar in women and men, LTRs were higher in women older than 85 years of age. LTR of dementia/AD at age 45 was 1 in 5 in women and 1 in 10 in men. Cardiovascular mortality was higher in men with rate ratios decreasing from approximately 6 at 45 to 54 years of age to less than 2 after age 65.ConclusionSelective survival of men with a healthier cardiovascular risk profile and hence lower propensity to dementia might partly explain the higher LTR of dementia/AD in women.

Funder

National Institute of Neurological Disorders and Stroke

Fondation Plan Alzheimer

National Heart, Lung, and Blood Institute

National Institutes of Health

Publisher

Wiley

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