Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

Author:

Mattsson Niklas1,Groot Colin2,Jansen Willemijn J.3,Landau Susan M.4,Villemagne Victor L.5,Engelborghs Sebastiaan6,Mintun Mark M.7,Lleo Alberto8,Molinuevo José Luis9,Jagust William J.4,Frisoni Giovanni B.1011,Ivanoiu Adrian12,Chételat Gaël13,Resende de Oliveira Catarina14,Rodrigue Karen M.15,Kornhuber Johannes16,Wallin Anders17,Klimkowicz‐Mrowiec Aleksandra18,Kandimalla Ramesh19,Popp Julius20,Aalten Pauline P.3,Aarsland Dag21,Alcolea Daniel8,Almdahl Ina S.22,Baldeiras Inês14,Buchem Mark A.23,Cavedo Enrica1124,Chen Kewei25,Cohen Ann D.26,Förster Stefan27,Fortea Juan8,Frederiksen Kristian S.28,Freund‐Levi Yvonne29,Gill Kiran Dip19,Gkatzima Olymbia30,Grimmer Timo31,Hampel Harald2432,Herukka Sanna‐Kaisa33,Johannsen Peter34,Laere Koen35,Leon Mony J.36,Maier Wolfgang37,Marcusson Jan38,Meulenbroek Olga39,Møllergård Hanne M.40,Morris John C.41,Mroczko Barbara42,Nordlund Arto43,Prabhakar Sudesh44,Peters Oliver45,Rami Lorena9,Rodríguez‐Rodríguez Eloy46,Roe Catherine M.41,Rüther Eckart47,Santana Isabel14,Schröder Johannes48,Seo Sang W.1,Soininen Hilkka49,Spiru Luiza50,Stomrud Erik1,Struyfs Hanne6,Teunissen Charlotte E.51,Verhey Frans R.J.3,Vos Stephanie J.B.3,Waalwijk van Doorn Linda J.C.5253,Waldemar Gunhild28,Wallin Åsa K.1,Wiltfang Jens1647,Vandenberghe Rik54,Brooks David J.55,Fladby Tormod22,Rowe Christopher C.27,Drzezga Alexander56,Verbeek Marcel M.5253,Sarazin Marie57,Wolk David A.58,Fleisher Adam S.225960,Klunk William E.26,Na Duk L.49,Sánchez‐Juan Pascual46,Lee Dong Young61,Nordberg Agneta62,Tsolaki Magda30,Camus Vincent63,Rinne Juha O.64,Fagan Anne M.41,Zetterberg Henrik65664367,Blennow Kaj1767,Rabinovici Gil D.40,Hansson Oskar1,Berckel Bart N.M.68,Flier Wiesje M.269,Scheltens Philip2,Visser Pieter Jelle23,Ossenkoppele Rik1268

Affiliation:

1. Clinical Memory Research UnitClinical Sciences MalmöLund UniversityLundSweden

2. Department of Neurology and Alzheimer CenterVU University Medical CenterNeuroscience Campus AmsterdamAmsterdamthe Netherlands

3. Department of Psychiatry and NeuropsychologySchool for Mental Health and NeuroscienceAlzheimer Center LimburgMaastricht UniversityMaastrichtthe Netherlands

4. Helen Wills Neuroscience InstituteUniversity of CaliforniaBerkeleyCAUSA

5. Department of Nuclear Medicine and Centre for PETAustin HealthMelbourneAustralia

6. Reference Center for Biological Markers of Dementia (BIODEM)University of AntwerpAntwerpBelgium

7. Avid RadiopharmaceuticalsPhiladelphiaPAUSA

8. Neurology DepartmentHospital de Sant PauBarcelonaSpain

9. Alzheimer's Disease and Other Cognitive Disorders UnitIDIBAPSClinic University HospitalBarcelonaSpain

10. Memory Clinic and LANVIE‐ Laboratory of Neuroimaging of AgingUniversity Hospitals and University of GenevaGenevaSwitzerland

11. Laboratory of Alzheimer's Neuroimaging and EpidemiologyIRCCS Centro San Giovanni di Dio FatebenefratelliBresciaItaly

12. Memory Clinic and Neurochemistry LaboratorySaint Luc University HospitalInstitute of NeuroscienceUniversité catholique de LouvainBrusselsBelgium

13. InsermInserm UMR‐S U1237Université de Caen‐NormandieGIP CyceronCaenFrance

14. Center for Neuroscience and Cell BiologyFaculty of MedicineCentro Hospitalar e Universitário de CoimbraCoimbraPortugal

15. Center for Vital LongevitySchool of Behavioral and Brain SciencesThe University of Texas at DallasDallasTXUSA

16. Department of Psychiatry and PsychotherapyFriedrich‐Alexander University of Erlangen‐ NurembergErlangenGermany

17. Institute of Neuroscience and PhysiologySahlgrenska Academy at University of GothenburgMölndalSweden

18. Jagiellonian University College of MedicineKrakowPoland

19. Department of BiochemistryPostgraduate Institute of Medical Education and Research (PGIMER)ChandigarhIndia

20. Department of PsychiatryService of Old Age PsychiatryUniversity Hospital of LausanneLausanneSwitzerland

21. Center for Age‐Related MedicineStavanger University HospitalStavangerNorway

22. Department of NeurologyAkershus University HospitalLørenskogNorway

23. Department of RadiologyLeiden University Medical CenterLeidenthe Netherlands

24. AXA Research Fund & UPMC ChairSorbonne UniversitésUniversité Pierre et Marie Curie (UPMC) Paris 06InsermCNRSInstitut du Cerveau et de la Moelle Épinière (ICM)Département de NeurologieInstitut de la Mémoire et de la Maladie d'Alzheimer (IM2A)Hôpital Pitié‐SalpêtrièreParisFrance

25. Banner Alzheimer's InstitutePhoenixAZUSA

26. University of Pittsburgh School of MedicineDepartment of PsychiatryPittsburghPAUSA

27. Department of Nuclear MedicineTechnische Universitaet MünchenMunichGermany

28. Danish Dementia Research CenterDepartment of NeurologyRigshospitaletUniversity of CopenhagenCopenhagenDenmark

29. Department of GeriatricsKarolinska University Hospital HuddingeSection of Clinical GeriatricsInstitution of NVSKarolinska InstitutetStockholmSweden

30. Third Department of NeurologyAristotle University of ThessalonikiThessalonikiGreece

31. Department of Psychiatry and PsychotherapyKlinikum rechts der Isar der Technischen Universitaet MünchenMunichGermany

32. Department of PsychiatryAlzheimer Memorial Center and Geriatric Psychiatry BranchLudwig‐Maximilian UniversityMunichGermany

33. Department of NeurologyUniversity of Eastern Finland and Kuopio University HospitalKuopioFinland

34. Memory ClinicDanish Dementia Research CenterRigshospitaletCopenhagenDenmark

35. Department of Imaging and PathologyCatholic University LeuvenLeuvenBelgium

36. School of MedicineCenter for Brain HealthNew York UniversityNew YorkNYUSA

37. Department of Psychiatry and PsychotherapyUniversity of BonnGerman Center for Neurodegenerative Diseases (DZNE)BonnGermany

38. Geriatric MedicineDepartment of Clinical and Experimental MedicineUniversity of LinköpingLinköpingSweden

39. Department of Geriatric MedicineRadboud Alzheimer CenterRadboud University Medical CenterNijmegenthe Netherlands

40. Department of NeurologyMemory and Aging CenterUniversity of CaliforniaSan FranciscoCAUSA

41. Knight Alzheimer's Disease Research CenterDepartment of NeurologyWashington University School of MedicineSt LouisMOUSA

42. Department of Neurodegeneration DiagnosticsLeading National Research Centre in Białystok (KNOW)Medical University of BiałystokBiałystokPoland

43. Institute of Neuroscience and PhysiologyDepartment of Psychiatry and NeurochemistryThe Sahlgrenska Academy at University of GothenburgMölndalSweden

44. Department of NeurologyPostgraduate Institute of Medical Education and Research (PGIMER)ChandigarhIndia

45. Department of Psychiatry and PsychotherapyCharité BerlinGerman Center for Neurodegenerative Diseases (DZNE)BerlinGermany

46. Neurology ServiceUniversitary Hospital Marqués de ValdecillaCIBERNEDIDIVALSantanderSpain

47. Department of Psychiatry and PsychotherapyUniversity Medical CenterGeorg‐August UniversityGöttingenGermany

48. Sektion GerontopsychiatrieUniversität HeidelbergHeidelbergGermany

49. Department of NeurologySamsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea

50. Department of Geriatrics‐Gerontology‐GerontopsychiatryCarol Davila University of Medicine and PharmacyBucharestRomania

51. Neurochemistry Laboratory and BiobankDepartment of Clinical ChemistryAmsterdam NeuroscienceVU University Medical CenterAmsterdamthe Netherlands

52. Department of NeurologyDonders Institute for BrainCognition and BehaviourRadboud Alzheimer CenterRadboud University Medical CenterNijmegenthe Netherlands

53. Department of Laboratory MedicineDonders Institute for BrainCognition and BehaviourRadboud Alzheimer CenterRadboud University Medical CenterNijmegenthe Netherlands

54. Laboratory for Cognitive Neurology and Alzheimer Research Centre KU LeuvenCatholic University LeuvenLeuvenBelgium

55. Division of NeuroscienceMedical Research Council Clinical Sciences CentreImperial College LondonLondonUK

56. Department of Nuclear MedicineUniversity of CologneCologneGermany

57. Neurologie de la Mémoire et du LangageCentre Hospitalier Sainte‐AnneUniversité Paris DescartesSorbonne Paris CitéParisFrance

58. Department of NeurologyUniversity of PennsylvaniaPhiladelphiaPAUSA

59. Eli LillyIndianapolisINUSA

60. Department of NeurosciencesUniversity of CaliforniaSan DiegoCAUSA

61. Department of NeuropsychiatrySeoul National UniversityCollege of MedicineSeoulSouth Korea

62. Department NVSCenter for Alzheimer ResearchTranslational Alzheimer NeurobiologyKarolinska Institutet and Geriatric MedicineKarolinska University HospitalStockholmSweden

63. CHRU de ToursCIC INSERM 1415INSERM U930Université François Rabelais de ToursToursFrance

64. Turku PET Centre and Division of Clinical Neurosciences TurkuUniversity of Turku and Turku University HospitalTurkuFinland

65. Department of Molecular NeuroscienceUCL Institute of NeurologyQueen SquareLondonUK

66. UK Dementia Research InstituteLondonUK

67. Sweden and Clinical Neurochemistry LaboratorySahlgrenska University HospitalMölndalSweden

68. Department of Radiology and Nuclear MedicineVU University Medical CenterNeuroscience Campus AmsterdamAmsterdamthe Netherlands

69. Department of Epidemiology and BiostatisticsVU University Medical CenterAmsterdamthe Netherlands

Funder

AXA Research Fund

National Institutes of Health

Indian Council of Medical Research

GE Healthcare

Instituto de Salud Carlos III

Eli Lilly and Company

Roche

Genentech

H. Lundbeck A/S

Novartis

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Fujirebio Europe

Avid Radiopharmaceuticals

AstraZeneca

Commonwealth Scientific and Industrial Research Organisation

National Health and Medical Research Council

Merck

Academy of Finland

European Commission

Itä-Suomen Yliopisto

Boehringer Ingelheim

KU Leuven

Biogen

ZonMw

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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